High 4OHE1 4OHE1 is a catechol estrogen formed by aromatic hydroxylation of primary estrogens at either the C-2 or C-4 position. 4OHE1 can be oxidized to catechol estrogen quinones if it is not inactivated by COMT and/or sulfation, glucuronidation, etc. These catechol quinones can react with DNA to produce an excess of estrogen-DNA adducts with…
Total Estrogen and Precision Medicine: Treating Our Patients vs. Treating the Population Throughout the history of medicine, healthcare trends have evolved toward disease prevention instead of treating disease. Yet, the flood of lifestyle and dietary changes designed to avoid certain diseases seems to be more of a marketing strategy for food distributors, health clubs and…
Jessica M. Faupel-Badger, Barbara J. Fuhrman, Xia Xu, Roni T. Falk, Larry K. Keefer, Timothy D. Veenstra, Robert N. Hoover, and Regina G. Ziegler Source: Cancer Epidemiol Biomarkers Prev. 2010 January ; 19(1): 292–300. doi:10.1158/1055-9965.EPI-09-0643. Abstract Absolute and relative concentrations of estrogens and estrogen metabolites (EM) are important for clinical decisions, as well as for…
J Am Pharm Assoc. 2003;43:724–6. – Jolena Hagen, Nicolette Gott, and Donald R. Miller Recent reports concerning the safety of hormone replacement therapy (HRT) have led many women to seek alternative ways to treat menopausal symptoms. A new alternative that has become very popular is bioidentical HRT. This therapy is often based on the results…
Source: Cancer Epidemiol Biomarkers Prev. 2008 December ; 17(12): 3411–3418. doi: 10.1158/1055-9965.EPI-08-0355. RT Falk1, X Xu2, L Keefer3, TD Veenstra2, and RG Ziegler1 Abstract Background—Accurate, reproducible, and sensitive measurements of endogenous estrogen exposure and individual patterns of estrogen metabolism are needed for etiologic studies of breast cancer. We have developed a high performance liquid chromatography-tandem mass spectrometry…