Hormone360 Complete · 5-Point Urine Collection
Hormone360 Complete: See the Rhythm
Behind the Results.
A comprehensive hormone and metabolite assessment with 5-point urine collection for expanded insight into cortisol, cortisone, adrenal function, and hormone metabolism throughout the day.
Hormones don’t remain constant throughout the day, and cortisol is especially dynamic.
Hormone360 Complete combines Physicians Lab’s comprehensive hormone and metabolite assessment with a 5-point urine collection, adding diurnal cortisol and cortisone patterns and 24-hour totals to provide a more complete picture of hormone and adrenal physiology.
Builds on Hormone360
Everything in Hormone360.
Plus diurnal insight.
Hormone360 Complete builds upon the comprehensive hormone and metabolite analysis of Hormone360. Providers receive the same broad assessment of:
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Estrogens and estrogen metabolism
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Progesterone and progesterone metabolism
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Androgens and androgen metabolism
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DHEA and related metabolites
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Cortisol and adrenal metabolism
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Hormone metabolic ratios
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Comprehensive pathway assessment
Hormone360 Complete then adds multiple urine collections throughout the day to show how cortisol and cortisone change over time.
Hormone360
Comprehensive Hormone & Metabolite Assessment
+ 5-Point Collection
Diurnal Cortisol & Cortisone Assessment
= Hormone360 Complete
A More Complete Hormone & Adrenal Picture
Why Diurnal Testing Matters
Cortisol Is a Rhythm,
not just a number.
Cortisol follows a natural daily pattern.
Levels are generally expected to change substantially from morning through evening. A single measurement can provide useful information, but it cannot show the shape of that daily pattern.
Hormone360 Complete evaluates cortisol and cortisone at multiple points throughout the day, allowing providers to visualize the patient’s diurnal pattern in addition to evaluating hormone and metabolite results.
Questions it helps answer
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What does the patient’s cortisol pattern look like throughout the day?
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Is the expected morning-to-evening rhythm present?
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How do cortisol and cortisone patterns compare?
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What is the patient’s total cortisol and cortisone output?
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How do these findings relate to the broader adrenal and hormone-metabolism picture?
5-Point Urine Collection
Five Collections.
A more complete picture.
Hormone360 Complete uses a convenient 5-point urine collection performed by the patient at home.
Samples collected at defined points throughout the day allow Physicians Lab to evaluate changes in cortisol and cortisone over time rather than relying on a single measurement.
5-Point Diurnal Cortisol
Visualize cortisol patterns throughout the day.
5-Point Diurnal Cortisone
Evaluate cortisone alongside cortisol to provide additional context around glucocorticoid metabolism.
24-Hour Cortisol
Assess total cortisol output across the collection period.
24-Hour Cortisone
Assess total cortisone output across the collection period.
What Hormone360 Complete Measures
The Full Hormone360 Panel.
Plus expanded diurnal testing.
Hormone360 Complete provides the full Hormone360 hormone and metabolite assessment plus expanded diurnal cortisol and cortisone testing.
Estrogens & Metabolism
9 markers
Estrone (E1)
Estradiol (E2)
Estriol (E3)
2-OH-E1
16α-OH-E1
4-OH-E1
2-Methoxy-E1
Estrogen Metabolites
Aromatase Activity
Progesterone & Metabolism
6 markers
5α-Pregnanediol
5β-Pregnanediol
Progesterone Metabolites
5α/5β Ratio
Progesterone Clearance
Postmenopausal PdG
Androgens & Metabolism
12 markers
Testosterone
DHT
Androsterone
Etiocholanolone
5α-Androstanediol
5β-Androstanediol
Androstenedione
DHEA
DHEA-S
Testosterone Metabolites
Testosterone/Metabolite Ratio
5α-Reductase Activity
Adrenal & Cortisol Metabolism
12 markers
Expanded with Hormone360 Complete
5-Point Diurnal Cortisol
5-Point Diurnal Cortisone
24-Hour Cortisol
24-Hour Cortisone
Waking Cortisol
Waking Cortisone
DHEA & DHEA-S
Cortisol Metabolites (THF, THE, α-THF, THS)
11β-Hydroxy Metabolites
Total Cortisol Metabolites
Cortisol Clearance
11β-HSD II Ratio
Metabolic Ratios & Pathways Assessment
7 markers
Total 17-Ketosteroids
Total 17-Hydroxysteroids
Cortisol Ratio
Anabolic/Catabolic Ratio
Estrogen Metabolism Ratios
Androgen Metabolism Ratios
Comprehensive Pathways Assessment
Parent Hormones + Metabolites + Daily Patterns
Three Layers
of hormone insight.
Hormone360 Complete is designed to give providers multiple layers of information rather than relying on an isolated hormone measurement.
Layer 1
Parent Hormones
What the body is producing.
Layer 2
Metabolites
How those hormones are being processed.
Layer 3
Daily Patterns
How cortisol and cortisone change across the day.
Clinical Applications
Designed for Personalized
hormone care.
Menopause & Perimenopause Management
Gain a broader view of estrogen, progesterone, androgen, and hormone-metabolite patterns during hormonal transition.
Bioidentical Hormone Therapy Monitoring
Evaluate hormone levels together with downstream metabolism to provide additional context when monitoring individualized hormone therapy.
Adrenal Function & Stress Assessment
Evaluate cortisol, cortisone, adrenal metabolites, and related pathways, with expanded diurnal assessment through Hormone360 Complete.
Men’s & Women’s Hormone Health
Assess sex hormones and their metabolites across both male and female hormone-health applications.
Functional & Integrative Medicine
Provide a more comprehensive view of interconnected hormone pathways for providers practicing personalized, functional, and integrative medicine.
Which test fits?
Hormone360
Best when a provider wants a comprehensive hormone and metabolite assessment with the convenience of a single first-morning urine collection.
Hormone360 Complete
Best when the clinical picture calls for comprehensive hormone and metabolite assessment plus a deeper evaluation of cortisol and cortisone patterns throughout the day.
Convenient At-Home Collection
Advanced Testing
without a trip to the lab.
Patients complete the Hormone360 Complete 5-point urine collection conveniently at home.
The specimens are returned to Physicians Lab for analysis, where hormone, metabolite, pathway, cortisol, and cortisone results are compiled into a comprehensive provider report.
Results Designed to Tell a Story
Clinical. Comprehensive.
Actionable.
Hormone360 Complete organizes complex hormone and metabolite data into a report designed to help providers recognize relationships between each layer of the picture.
Step 1
Hormone Production
Step 2
Hormone Metabolism
Step 3
Cortisol & Cortisone Patterns
Step 4
Metabolic Ratios & Pathways
Step 5
Clinical Context
The addition of diurnal cortisol and cortisone patterns gives providers another dimension of information when evaluating the patient’s overall hormone and adrenal picture.
Go Beyond Hormones & Adrenal Function
Total360 Complete:
our most comprehensive assessment.
For providers seeking Physicians Lab’s broadest assessment, Total360 Complete combines Hormone360 Complete with MPP, the Metabolic Performance Panel.
Total360 Complete expands the picture beyond hormone and adrenal physiology to include metabolic pathways, amino acids, nutrient-related metabolism, methylation, cellular energy, oxidative stress, and other areas of metabolic function.
Hormone360 Complete
Hormones + Metabolites + Diurnal Assessment
+ MPP
Metabolic & Pathway Function
= Total360 Complete
Our Most Comprehensive Assessment
A More Complete Hormone Picture
Bring Hormone360 Complete
to your practice.
Hormone360 Complete combines comprehensive hormone and metabolite testing with expanded diurnal cortisol and cortisone assessment, giving providers a deeper view of hormone production, metabolism, adrenal function, and daily hormone patterns.
Clinical. Comprehensive. Actionable.